SLC5A8

Across TCGA pan-cancer cohorts, SLC5A8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SLC5A8’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SLC5A8 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC5A8 is over-expressed in tumor, although a few such as THCA and HNSC show the opposite, repressed pattern.

THCA, HNSC, and KICH are the cancer types where SLC5A8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC5A8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−5.854	<.001	11	view →
HNSC	All	II,III,IV	−0.999	<.001	11	view →
KICH	Male	IV	−3.420	<.001	10	view →
LUAD	All	II,III,IV	−1.347	<.001	8	view →
LUSC	Male	II,III,IV	−2.231	<.001	6	view →
BRCA	Female	II,III,IV	+0.773	<.001	4	view →
COAD	Female	All	−0.293	.002	4	view →
KIRC	Female	All	+1.631	.001	2	view →
KIRP	All	III,IV	−1.247	.025	2	view →
READ	All	All	−0.415	.007	2	view →
CHOL	All	All	+1.558	.013	1	view →
ESCA	Female	All	−0.049	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SLC5A8–THCA

Open the THCA breakdown →