SLC5A8

Across TCGA pan-cancer cohorts, SLC5A8 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SLC5A8 data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLC5A8 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SLC5A8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and KIRP are the cancer types where SLC5A8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.468	0.298	<.001	119	view →
KIRC	DFS	Median	All	0.709	0.537	<.001	118	view →
KIRP	DFS	Median	II,III,IV	0.891	0.236	<.001	77	view →
LIHC	OS	Tertile	All	0.560	0.728	<.001	48	view →
SKCM	OS	Quartile	III,IV	0.549	0.802	<.001	45	view →
CESC	OS	Quartile	III,IV	0.540	0.855	.002	36	view →
LAML	DFS	Median	All	0.552	0.383	.010	36	view →
UVM	DFS	Tertile	III,IV	0.172	0.711	.016	27	view →
PRAD	DFS	Median	All	0.888	0.666	<.001	18	view →
ACC	OS	Median	IV	0.798	0.288	.012	12	view →
OV	OS	Tertile	IV	0.547	0.261	.021	12	view →
UCEC	OS	Median	All	0.946	0.908	.019	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SLC5A8–HNSC (OS)

Open the HNSC breakdown →