SLC5A8

Across TCGA patient cohorts, SLC5A8 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC5A8-associated genes across cancer lineages are PDCD4, C-Raf, and Cyclin-E2. Each is linked with SLC5A8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC5A8-to-partner and partner-to-SLC5A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SLC5A8-low versus SLC5A8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A8→partner) and Y-score (partner→SLC5A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PDCD4 →	-0.538	-3.000	.009	.035	3	3
UCEC	C-Raf →	+0.142	+2.087	.003	.005	3	3
UCEC	Cyclin-E2 →	+0.123	+1.495	.032	.034	3	3
UCEC	EGFR →	-0.138	-1.247	.011	.045	3	2
UCEC	eIF4E →	+0.178	+2.321	.013	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.165	-3.000	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

PDCD4 by SLC5A8 expression — COAD

Explore this box plot interactively →