SLC5A8

Across TCGA cell cohorts, SLC5A8 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLC5A8-associated genes across cancer lineages are H2BC1, SPRR2G, and H2AC1. Each is linked with SLC5A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC5A8-to-partner and partner-to-SLC5A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC1 grouped by SLC5A8-low versus SLC5A8-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC5A8→partner) and Y-score (partner→SLC5A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1
SOFT_TISSUE	SPRR2G →	+0.679	+4.930	<.001	.008	3	1
SOFT_TISSUE	H2AC1 →	+0.193	+5.977	<.001	.001	3	1
SOFT_TISSUE	H2AP →	+0.069	+4.930	<.001	.008	3	1
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	1
SOFT_TISSUE	GAGE12E →	+0.090	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

H2BC1 by SLC5A8 expression — SOFT_TISSUE

Explore this box plot interactively →