SLC4A8

Across TCGA cell cohorts, SLC4A8 mutation is significantly associated with the RNA expression of many other genes, with 474 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC4A8-associated genes across cancer lineages are PRKACG, CA5A, and MMP27. Each is linked with SLC4A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC4A8-to-partner and partner-to-SLC4A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKACG grouped by SLC4A8-low versus SLC4A8-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC4A8→partner) and Y-score (partner→SLC4A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PRKACG →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	CA5A →	+0.020	+5.087	<.001	.004	3	1
PANCREAS	MMP27 →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	POTEB →	+0.016	+5.000	<.001	.006	3	1
SKIN	NEUROD4 →	+0.061	+2.669	.004	.004	3	1
SKIN	ZNF705G →	+0.018	+2.560	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 474 associations by consensus.

PRKACG by SLC4A8 expression — URINARY_TRACT

Explore this box plot interactively →