SLC38A5

Across TCGA patient cohorts, SLC38A5 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC38A5-associated genes across cancer lineages are PI3K-p110-a, ATM, and ERK2. Each is linked with SLC38A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC38A5-to-partner and partner-to-SLC38A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p110-a grouped by SLC38A5-low versus SLC38A5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC38A5→partner) and Y-score (partner→SLC38A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PI3K-p110-a →	-0.126	-2.415	.036	.003	3	2
UCEC	ATM →	-0.595	-3.087	<.001	<.001	3	2
UCEC	ERK2 →	+0.157	+1.807	.016	.004	3	1
UCEC	Gab2 →	+0.283	+1.514	.020	.015	3	1
UCEC	JNK2 →	+0.147	+1.763	.030	.048	3	1
UCEC	MSH2 →	-0.271	-3.781	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PI3K-p110-a by SLC38A5 expression — UCEC

Explore this box plot interactively →