SLC38A5

Across TCGA pan-cancer cohorts, SLC38A5 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SLC38A5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLC38A5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC38A5 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

COAD, KICH, and STAD are the cancer types where SLC38A5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC38A5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+2.480	<.001	12	view →
KICH	Male	II,III,IV	−1.937	<.001	11	view →
STAD	Male	IV	+3.030	.006	6	view →
UCEC	All	All	−1.421	<.001	6	view →
BRCA	All	III,IV	+1.310	<.001	6	view →
HNSC	All	All	+1.168	<.001	6	view →
LIHC	All	All	+0.350	.001	6	view →
LUAD	All	All	−0.559	<.001	5	view →
CHOL	All	All	+1.549	.008	2	view →
BLCA	All	III,IV	+1.051	.019	2	view →
PRAD	All	All	−0.828	<.001	2	view →
READ	Female	All	+1.742	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SLC38A5–COAD

Open the COAD breakdown →