SLC38A5

Across TCGA pan-cancer cohorts, SLC38A5 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SLC38A5 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SLC38A5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLC38A5 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

KIRC, STAD, and KIRP are the cancer types where SLC38A5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.537	0.719	<.001	117	view →
STAD	DFS	Quartile	II,III,IV	0.450	0.723	.001	51	view →
KIRP	DFS	Quartile	III,IV	0.290	0.732	.007	50	view →
UVM	DFS	Median	All	0.423	0.714	.001	47	view →
LUAD	OS	Tertile	II,III,IV	0.739	0.432	<.001	47	view →
OV	OS	Tertile	IV	0.230	0.500	.002	42	view →
UCEC	DFS	Quartile	IV	0.970	0.499	.005	36	view →
SKCM	DFS	Median	IV	0.745	0.150	<.001	34	view →
PAAD	DFS	Quartile	All	0.297	0.529	.002	33	view →
UCS	DFS	Median	II,III,IV	0.616	0.273	.002	22	view →
PRAD	DFS	Quartile	All	0.977	0.905	.007	16	view →
ACC	DFS	Tertile	All	0.793	0.517	.048	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SLC38A5–KIRC (OS)

Open the KIRC breakdown →