SLC36A4

Across TCGA cell cohorts, SLC36A4 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC36A4-associated genes across cancer lineages are SPINT4, USP17L15, and OR5M10. Each is linked with SLC36A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC36A4-to-partner and partner-to-SLC36A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINT4 grouped by SLC36A4-low versus SLC36A4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC36A4→partner) and Y-score (partner→SLC36A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPINT4 →	+0.054	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	USP17L15 →	+0.016	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR5M10 →	+0.019	+5.662	<.001	.002	3	1
LARGE_INTESTINE	TBX18 →	+1.048	+3.215	.001	.009	3	1
LARGE_INTESTINE	CHST8 →	+0.150	+2.906	<.001	.004	3	1
LARGE_INTESTINE	SRMS →	+1.102	+3.125	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

SPINT4 by SLC36A4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →