SLC36A4

Across TCGA pan-cancer cohorts, SLC36A4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SLC36A4 data layer compared with 3 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SLC36A4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC36A4 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCS show a favorable association.

ACC, COAD, and UCS are the cancer types where SLC36A4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.365	0.790	<.001	83	view →
COAD	OS	Tertile	All	0.966	0.777	<.001	82	view →
UCS	DFS	Median	IV	0.952	0.367	.001	66	view →
UVM	DFS	Tertile	III,IV	0.249	0.848	.002	63	view →
KICH	OS	Tertile	All	0.635	1.000	.001	53	view →
LGG	OS	Median	All	0.722	0.896	<.001	53	view →
LIHC	OS	Tertile	All	0.647	0.846	<.001	51	view →
KIRP	DFS	Tertile	IV	0.128	0.667	.004	45	view →
BLCA	DFS	Quartile	III,IV	0.327	0.506	.017	26	view →
LUAD	OS	Median	All	0.287	0.417	.003	26	view →
UCEC	DFS	Median	All	0.792	0.880	.002	24	view →
READ	OS	Quartile	III,IV	1.000	0.420	.007	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SLC36A4–ACC (DFS)

Open the ACC breakdown →