SLC36A4

Across TCGA pan-cancer cohorts, SLC36A4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SLC36A4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC36A4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC36A4 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LUAD, and THCA are the cancer types where SLC36A4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC36A4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+0.815	<.001	12	view →
LUAD	Male	II,III,IV	+1.044	<.001	9	view →
THCA	Male	All	−0.523	<.001	9	view →
KICH	Female	All	−1.180	<.001	7	view →
KIRP	Female	II,III,IV	+1.191	.015	6	view →
LIHC	All	All	+0.376	<.001	6	view →
CHOL	All	All	+1.175	<.001	5	view →
PRAD	All	All	−0.250	.006	2	view →
LUSC	Female	II,III,IV	−0.552	.031	1	view →
COAD	Male	All	+0.357	.020	1	view →
ESCA	Female	All	+0.356	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SLC36A4–HNSC

Open the HNSC breakdown →