SLC36A4

Across TCGA cell cohorts, SLC36A4 mutation is significantly associated with the mutation status of many other genes, with 2,907 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC36A4-associated genes across cancer lineages are DCC, KCNT2, and WDR62. Each is linked with SLC36A4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC36A4-to-partner and partner-to-SLC36A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCC grouped by SLC36A4-low versus SLC36A4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC36A4→partner) and Y-score (partner→SLC36A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DCC →	+2.854	+3.404	<.001	<.001	1	3
LARGE_INTESTINE	KCNT2 →	+3.632	+3.392	<.001	<.001	1	3
LUNG_NSCLC_LUAD	WDR62 →	+4.772	+5.339	.004	.004	1	2
LUNG_NSCLC_LUAD	MTMR2 →	+5.772	+5.772	.002	.002	1	2
LUNG_NSCLC_LUAD	FAM120B →	+5.772	+5.772	.002	.002	1	2
LUNG_NSCLC_LUAD	BCAR3 →	+4.187	+5.000	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,907 associations by consensus.

DCC by SLC36A4 expression — LARGE_INTESTINE

Explore this box plot interactively →