SLC25A2

Across TCGA patient cohorts, SLC25A2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A2-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and Notch1. Each is linked with SLC25A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A2-to-partner and partner-to-SLC25A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SLC25A2-low versus SLC25A2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A2→partner) and Y-score (partner→SLC25A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.424	+2.824	<.001	.034	3	2
UCEC	eIF4E →	+0.201	+2.584	.024	.010	3	2
UCEC	Notch1 →	+0.190	+2.183	.001	.033	3	2
UCEC	EGFR →	-0.210	-2.295	.001	.033	3	1
UCEC	ERK2 →	+0.194	+3.321	.017	.010	3	1
UCEC	FoxM1 →	+0.234	+2.222	.033	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Caspase-7-cleavedD198 by SLC25A2 expression — COAD

Explore this box plot interactively →