SLC25A2

Across TCGA pan-cancer cohorts, SLC25A2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SLC25A2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLC25A2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC25A2 is over-expressed in tumor, although a few such as UCEC and LIHC show the opposite, repressed pattern.

COAD, KIRC, and ESCA are the cancer types where SLC25A2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC25A2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.094	<.001	6	view →
KIRC	Male	II,III,IV	+0.076	.003	5	view →
ESCA	All	All	+0.212	.029	4	view →
LUSC	All	II,III,IV	+0.109	.005	4	view →
HNSC	All	All	+0.027	.005	3	view →
UCEC	All	IV	−0.150	.035	2	view →
PRAD	All	All	+0.118	.002	2	view →
BLCA	All	All	+0.114	.039	2	view →
THCA	All	All	+0.051	.005	2	view →
LIHC	Male	II,III,IV	−0.023	.030	2	view →
LUAD	All	All	+0.107	.023	1	view →
KICH	All	All	−0.050	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SLC25A2–COAD

Open the COAD breakdown →