SLC25A2

Across TCGA pan-cancer cohorts, SLC25A2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SLC25A2 data layer compared with 5 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher SLC25A2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC25A2 expression acts as an unfavorable survival marker, although some lineages such as SCLC and CHOL show a favorable association.

SCLC, ACC, and KIRC are the cancer types where SLC25A2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Tertile	II,III,IV	0.605	0.189	.001	89	view →
ACC	OS	Quartile	All	0.307	0.835	<.001	73	view →
KIRC	OS	Median	All	0.537	0.705	<.001	72	view →
KIRP	DFS	Quartile	III,IV	0.296	0.800	<.001	44	view →
BLCA	DFS	Tertile	IV	0.309	0.550	.001	41	view →
UVM	OS	Tertile	III,IV	0.273	0.848	.001	27	view →
THCA	DFS	Median	III,IV	0.585	0.916	.003	24	view →
CHOL	OS	Tertile	II,III,IV	0.794	0.284	.021	22	view →
ESCA	DFS	Quartile	All	1.000	0.378	.011	15	view →
STAD	DFS	Tertile	III,IV	0.752	0.431	.011	15	view →
LIHC	OS	Median	All	0.668	0.454	.010	15	view →
THYM	DFS	Median	II,III,IV	0.643	0.957	.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SLC25A2–SCLC (DFS)

Open the SCLC breakdown →