SLC25A2

Across TCGA cell cohorts, SLC25A2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,750 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SLC25A2-associated GO terms across cancer lineages are Regulation of protein localization to endoplasmic reticulum, Positive regulation of double-strand break repair, and Negative regulation of DNA-templated transcription initiation. Each is linked with SLC25A2 in more than 6 cancer types. Because this analysis shows association rather than direction, both SLC25A2-to-partner and partner-to-SLC25A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to endoplasmic reticulum grouped by SLC25A2-low versus SLC25A2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A2→partner) and Y-score (partner→SLC25A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to endoplasmic reticulum →	+0.119	+0.080	<.001	.004	3	7
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.066	+0.069	.002	.006	3	7
PANCREAS	Negative regulation of DNA-templated transcription initiation →	+0.075	+0.045	.002	.004	3	7
PANCREAS	Negative regulation of transcription initiation by RNA polymerase II →	+0.075	+0.045	.002	.004	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair →	+0.045	+0.052	.001	.005	3	7
CNS	Cytosolic transport →	+0.044	+0.057	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,750 associations by consensus.

Regulation of protein localization to endoplasmic reticulum by SLC25A2 expression — UPPER_AERODIGESTIVE_TRACT

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