SLC1A4

Across TCGA patient cohorts, SLC1A4 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC1A4-associated genes across cancer lineages are Lck, EGFR_pY1068, and Ku80. Each is linked with SLC1A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC1A4-to-partner and partner-to-SLC1A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by SLC1A4-low versus SLC1A4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC1A4→partner) and Y-score (partner→SLC1A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.184	+2.115	.035	.019	3	2
UCEC	EGFR_pY1068 →	-0.332	-2.807	.002	.003	3	1
UCEC	Ku80 →	+0.233	+2.128	.023	.010	3	1
UCEC	MEK1 →	+0.322	+2.115	.044	.019	3	1
UCEC	PDCD4 →	-0.502	-2.999	.014	.035	3	1
UCEC	Annexin-1 →	+0.523	+3.341	.023	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Lck by SLC1A4 expression — UCEC

Explore this box plot interactively →