SLC1A4

Across TCGA cell cohorts, SLC1A4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,260 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SLC1A4-associated GO terms across cancer lineages are L-cystine transport, Proline transmembrane transport, and L-glutamate import across plasma membrane. Each is linked with SLC1A4 in more than 13 cancer types. Because this analysis shows association rather than direction, both SLC1A4-to-partner and partner-to-SLC1A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-cystine transport grouped by SLC1A4-low versus SLC1A4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC1A4→partner) and Y-score (partner→SLC1A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	L-cystine transport →	+0.906	+1.429	.003	.003	3	14
BLOOD_Myeloma	Proline transmembrane transport →	+0.198	+1.671	<.001	<.001	2	14
SOFT_TISSUE	L-glutamate import across plasma membrane →	+1.083	+1.503	<.001	<.001	3	13
BLOOD_Myeloma	Intracellular amino acid homeostasis →	+0.190	+1.765	<.001	<.001	3	11
BLOOD_Myeloma	L-glutamine transport →	+0.170	+1.589	<.001	<.001	3	9
LUNG_SCLC	Intracellular glutamate homeostasis →	+0.198	+1.350	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,260 associations by consensus.

L-cystine transport by SLC1A4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →