SLC17A6

Across TCGA patient cohorts, SLC17A6 mutation is significantly associated with the RNA expression of many other genes, with 5,032 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC17A6-associated genes across cancer lineages are ZNF598, SKA1, and PGAM5. Each is linked with SLC17A6 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC17A6-to-partner and partner-to-SLC17A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF598 grouped by SLC17A6-low versus SLC17A6-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC17A6→partner) and Y-score (partner→SLC17A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ZNF598 →	+0.599	+3.203	.005	.009	3	5
UCEC	SKA1 →	+0.755	+2.098	<.001	<.001	3	5
UCEC	PGAM5 →	+0.605	+2.087	<.001	<.001	3	4
LUAD	RAD54L →	+0.662	+3.011	.009	<.001	3	4
UCEC	TIMM13 →	+0.476	+3.445	<.001	<.001	3	4
UCEC	EMC8 →	+0.517	+2.627	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,032 associations by consensus.

ZNF598 by SLC17A6 expression — STAD

Explore this box plot interactively →