SLC17A6

Across TCGA pan-cancer cohorts, SLC17A6 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated SLC17A6 data layer compared with 10 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SLC17A6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC17A6 expression acts as an unfavorable survival marker, although some lineages such as LGG and ESCA show a favorable association.

UCEC, COAD, and DLBC are the cancer types where SLC17A6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.713	0.860	<.001	132	view →
COAD	DFS	Tertile	III,IV	0.274	0.681	<.001	114	view →
DLBC	OS	Tertile	III,IV	0.154	0.735	.010	46	view →
UCS	DFS	Tertile	All	0.370	0.637	.024	42	view →
LGG	DFS	Tertile	All	0.584	0.380	<.001	37	view →
KIRC	DFS	Tertile	IV	0.388	0.670	.016	24	view →
CHOL	OS	Tertile	All	0.089	0.673	.018	18	view →
UVM	OS	Quartile	All	0.362	0.746	.016	16	view →
SARC	OS	Tertile	All	0.717	0.861	.012	15	view →
ESCA	OS	Tertile	III,IV	0.605	0.328	.031	15	view →
SCLC	DFS	Median	II,III,IV	0.566	0.284	.019	13	view →
PRAD	DFS	Tertile	All	1.000	0.723	.027	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

SLC17A6–UCEC (DFS)

Open the UCEC breakdown →