SLC17A6

Across TCGA patient cohorts, SLC17A6 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC17A6-associated genes across cancer lineages are Cyclin-E2, Cyclin-B1, and EGFR_pY1068. Each is linked with SLC17A6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC17A6-to-partner and partner-to-SLC17A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by SLC17A6-low versus SLC17A6-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC17A6→partner) and Y-score (partner→SLC17A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Cyclin-E2 →	+0.100	+2.124	.048	.010	3	3
UCEC	Cyclin-B1 →	+0.554	+1.584	<.001	.002	3	3
UCEC	EGFR_pY1068 →	-0.224	-1.584	.002	.002	3	3
UCEC	Notch1 →	+0.149	+1.861	<.001	.004	3	3
UCEC	4E-BP1 →	+0.311	+2.614	<.001	<.001	3	3
LUSC	TIGAR →	+0.164	+1.888	.003	.028	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Cyclin-E2 by SLC17A6 expression — LUSC

Explore this box plot interactively →