SLAMF9

Across TCGA patient cohorts, SLAMF9 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLAMF9-associated genes across cancer lineages are p62 Lck ligand, IGFBP2, and PI3K-p85. Each is linked with SLAMF9 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLAMF9-to-partner and partner-to-SLAMF9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by SLAMF9-low versus SLAMF9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLAMF9→partner) and Y-score (partner→SLAMF9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p62 Lck ligand →	+0.340	+3.472	.042	.002	3	2
SKCM	IGFBP2 →	-0.454	-3.000	.041	.035	3	1
SKCM	PI3K-p85 →	+0.248	+3.597	.006	.001	3	1
SKCM	XBP1 →	-0.230	-3.169	.031	.017	3	1
SKCM	4E-BP1_pT70 →	+0.168	+2.824	.032	.034	3	1
UCEC	Cyclin-B1 →	+0.556	+2.321	.049	.035	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

p62 Lck ligand by SLAMF9 expression — SKCM

Explore this box plot interactively →