SLAMF9

Across TCGA pan-cancer cohorts, SLAMF9 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SLAMF9’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLAMF9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLAMF9 is over-expressed in tumor.

HNSC, COAD, and LUAD are the cancer types where SLAMF9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLAMF9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+2.309	<.001	12	view →
COAD	All	III,IV	+1.142	<.001	11	view →
LUAD	All	III,IV	+1.608	<.001	9	view →
THCA	Male	All	+0.294	<.001	9	view →
BLCA	All	All	+0.572	.005	8	view →
KIRC	All	All	+0.184	.002	8	view →
UCEC	All	All	+0.468	.002	6	view →
LUSC	Male	All	+1.290	<.001	5	view →
BRCA	All	All	+0.263	.019	4	view →
KIRP	All	All	+0.355	.002	3	view →
READ	All	III,IV	+0.800	.027	2	view →
STAD	All	All	+0.355	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SLAMF9–HNSC

Open the HNSC breakdown →