SKP2

Across TCGA patient cohorts, SKP2 mutation is significantly associated with the RNA expression of many other genes, with 1,061 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SKP2-associated genes across cancer lineages are RNY3P2, HERC2P11, and IFNA8. Each is linked with SKP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SKP2-to-partner and partner-to-SKP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY3P2 grouped by SKP2-low versus SKP2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKP2→partner) and Y-score (partner→SKP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNY3P2 →	+0.409	+5.081	<.001	.004	3	3
LUAD	HERC2P11 →	+0.051	+3.491	.005	.008	3	2
HNSC	IFNA8 →	+0.064	+4.320	.001	.007	3	2
UCEC	YTHDF3-AS1 →	+0.756	+2.556	<.001	.001	3	1
UCEC	COPS8P1 →	+0.069	+1.941	.002	.009	3	1
UCEC	CCL5 →	+1.117	+3.191	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,061 associations by consensus.

RNY3P2 by SKP2 expression — LUSC

Explore this box plot interactively →