SKA1

Across TCGA patient cohorts, SKA1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,754 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SKA1-associated genes across cancer lineages are KIF23, SKA3, and POLQ. Each is linked with SKA1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SKA1-to-partner and partner-to-SKA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SKA1 versus KIF23 in BRCA, with a Pearson correlation of 0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKA1→partner) and Y-score (partner→SKA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIF23 →	+1.256	+0.862	<.001	<.001	3	6
GBM	SKA3 →	+1.401	+0.941	<.001	<.001	3	6
OV	POLQ →	+1.701	+1.098	<.001	<.001	3	6
OV	UBE2S →	+1.403	+0.871	.002	<.001	3	5
OV	NCAPG →	+2.477	+1.396	<.001	<.001	3	5
OV	FBXO5 →	+1.653	+1.465	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,754 associations by consensus.

SKA1 vs KIF23 — BRCA

Explore this scatter interactively →