Across TCGA patient cohorts, SIX6 mutation is significantly associated with the RNA expression of many other genes, with 618 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIX6-associated genes across cancer lineages are LINC02216, NIFKP9, and RNF40. Each is linked with SIX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX6-to-partner and partner-to-SIX6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX6→partner) and Y-score (partner→SIX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC02216 →	+0.116	+4.513	.008	.005	3	2
LUAD	NIFKP9 →	+0.220	+5.197	<.001	.003	3	2
SCLC	RNF40 →	+3.877	+4.299	<.001	.002	3	1
SCLC	GABRA6 →	+0.160	+3.819	<.001	.007	3	1
SCLC	DEFB135 →	+0.582	+4.039	<.001	.009	3	1
BRCA	MIR6894 →	+0.395	+4.506	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 618 associations by consensus.

Exploration

SIX6 survival (RNA) · tumor vs normal (RNA) · all SIX6 data types