Across TCGA pan-cancer cohorts, SIX6 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SIX6’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SIX6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SIX6 is over-expressed in tumor.

LUSC and LUAD are the cancer types where SIX6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIX6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+0.049	.004	3	view →
LUAD	Male	All	+0.030	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SIX6 RNA expression & survival · all SIX6 data types