Across TCGA cell cohorts, SIX6 mutation is significantly associated with the mutation status of many other genes, with 1,733 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIX6-associated genes across cancer lineages are KCNH6, GPC5, and RREB1. Each is linked with SIX6 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIX6-to-partner and partner-to-SIX6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX6→partner) and Y-score (partner→SIX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCNH6 →	+3.560	+4.247	.002	.002	1	3
SOFT_TISSUE	GPC5 →	+5.502	+5.502	.003	.003	1	3
LUNG_NSCLC_LUAD	RREB1 →	+3.303	+3.478	.006	.006	1	3
LUNG_NSCLC_LUAD	RADIL →	+3.396	+4.078	<.001	<.001	1	3
BLOOD_Leukemia	CREBBP →	+2.037	+3.830	.008	.008	1	3
LUNG_NSCLC_LUAD	WRN →	+3.396	+4.078	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,733 associations by consensus.

Exploration

SIX6 survival (RNA) · tumor vs normal (RNA) · all SIX6 data types