SIX4

Across TCGA patient cohorts, SIX4 mutation is significantly associated with the RNA expression of many other genes, with 5,724 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIX4-associated genes across cancer lineages are MIR373, CEP85, and RN7SL248P. Each is linked with SIX4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SIX4-to-partner and partner-to-SIX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR373 grouped by SIX4-low versus SIX4-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX4→partner) and Y-score (partner→SIX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR373 →	+0.418	+4.526	<.001	.007	3	4
SKCM	CEP85 →	+0.590	+3.331	.006	.005	3	3
UCEC	RN7SL248P →	+0.052	+2.864	<.001	.001	3	3
ESCA	RNU6-793P →	+0.356	+5.450	<.001	.004	3	3
UCEC	UBE2F →	+0.318	+1.914	<.001	<.001	3	3
SKCM	LINC01128 →	+0.434	+3.360	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,724 associations by consensus.

MIR373 by SIX4 expression — HNSC

Explore this box plot interactively →