SIX4

Across TCGA cell cohorts, SIX4 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIX4-associated genes across cancer lineages are DPPA2, RPL10L, and CSN3. Each is linked with SIX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX4-to-partner and partner-to-SIX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPPA2 grouped by SIX4-low versus SIX4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX4→partner) and Y-score (partner→SIX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DPPA2 →	+0.339	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	RPL10L →	+0.191	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	CSN3 →	+0.183	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	ZNF804B →	+0.013	+4.350	<.001	.005	3	1
OVARY	KRT85 →	+0.030	+3.898	.002	.005	3	1
OVARY	OR1Q1 →	+0.148	+3.898	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

DPPA2 by SIX4 expression — BLOOD_Lymphoma

Explore this box plot interactively →