SIX3

Across TCGA patient cohorts, SIX3 mutation is significantly associated with the RNA expression of many other genes, with 3,639 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIX3-associated genes across cancer lineages are RN7SL248P, RNA5SP412, and ATP5MC3. Each is linked with SIX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX3-to-partner and partner-to-SIX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by SIX3-low versus SIX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX3→partner) and Y-score (partner→SIX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.080	+3.552	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.884	+2.159	<.001	.001	3	2
UCEC	ATP5MC3 →	+0.432	+2.716	.008	<.001	3	2
UCEC	SFXN1 →	+0.707	+4.021	<.001	<.001	3	2
UCEC	TIMM22 →	+0.523	+4.445	<.001	<.001	3	2
UCEC	GLRX2 →	+0.443	+1.776	.008	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,639 associations by consensus.

RN7SL248P by SIX3 expression — UCEC

Explore this box plot interactively →