SIX3

Across TCGA pan-cancer cohorts, SIX3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SIX3 data layer compared with 3 for mutation status.

The strongest signal is observed in acute myeloid leukemia (LAML), where higher SIX3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SIX3 expression acts as an unfavorable survival marker, although some lineages such as LAML and BLCA show a favorable association.

LAML, LIHC, and LGG are the cancer types where SIX3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LAML	DFS	Median	All	0.504	0.254	<.001	42	view →
LIHC	OS	Tertile	All	0.427	0.605	.001	37	view →
LGG	OS	Tertile	All	0.843	0.927	<.001	35	view →
ESCA	OS	Median	All	0.590	0.777	.007	33	view →
KIRC	DFS	Tertile	All	0.512	0.702	.016	26	view →
MESO	DFS	Tertile	IV	0.332	0.712	.024	19	view →
LUSC	DFS	Tertile	III,IV	0.401	0.639	.013	16	view →
PRAD	DFS	Median	All	0.835	0.929	<.001	16	view →
UCS	OS	Median	III,IV	0.216	0.556	.019	12	view →
BLCA	OS	Median	All	0.534	0.237	.016	12	view →
CESC	DFS	Quartile	IV	0.261	0.611	.037	12	view →
UCEC	OS	Median	II,III,IV	0.706	0.821	.027	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SIX3–LAML (DFS)

Open the LAML breakdown →