SIX3-AS1

Across TCGA patient cohorts, SIX3-AS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,864 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible SIX3-AS1-associated GO terms across cancer lineages are Motile cilium assembly, Regulation of DNA replication, and Cytoskeleton-dependent cytokinesis. Each is linked with SIX3-AS1 in more than 12 cancer types. Because this analysis shows association rather than direction, both SIX3-AS1-to-partner and partner-to-SIX3-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Motile cilium assembly grouped by SIX3-AS1-low versus SIX3-AS1-high in UCEC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX3-AS1→partner) and Y-score (partner→SIX3-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Motile cilium assembly →	+0.037	+0.345	<.001	<.001	3	13
STAD	Regulation of DNA replication →	+0.053	+0.157	<.001	<.001	3	13
STAD	Cytoskeleton-dependent cytokinesis →	+0.049	+0.171	<.001	<.001	3	12
STAD	Nuclear membrane organization →	+0.075	+0.235	<.001	<.001	3	12
STAD	Positive regulation of nuclear cell cycle DNA replication →	+0.046	+0.188	<.001	<.001	3	12
KIRP	Positive regulation of protein localization to cilium →	+0.035	+0.227	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,864 associations by consensus.

Motile cilium assembly by SIX3-AS1 expression — UCEC

Explore this box plot interactively →