SIX3-AS1

Across TCGA pan-cancer cohorts, SIX3-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SIX3-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where SIX3-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SIX3-AS1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

BRCA, KIRC, and LUSC are the cancer types where SIX3-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIX3-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	+0.298	<.001	6	view →
KIRC	All	All	−0.044	<.001	6	view →
LUSC	All	II,III,IV	+0.158	.018	4	view →
STAD	Male	III,IV	+0.245	.029	3	view →
LUAD	All	IV	+0.885	.041	2	view →
UCEC	All	All	+0.346	.004	2	view →
KICH	All	All	−0.075	.019	2	view →
PRAD	All	All	+0.016	.035	2	view →
LIHC	All	All	+0.029	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SIX3-AS1–BRCA

Open the BRCA breakdown →