SIX3-AS1

Across TCGA pan-cancer cohorts, SIX3-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SIX3-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SIX3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SIX3-AS1 expression acts as an unfavorable survival marker, although some lineages such as LAML and OV show a favorable association.

KIRC, SKCM, and MESO are the cancer types where SIX3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.643	0.823	.003	138	view →
SKCM	OS	Tertile	All	0.205	0.365	.001	62	view →
MESO	OS	Tertile	III,IV	0.044	0.610	<.001	54	view →
ACC	DFS	Tertile	IV	0.010	0.383	<.001	45	view →
UCS	OS	Median	III,IV	0.294	0.591	.008	38	view →
LGG	OS	Tertile	All	0.835	0.919	<.001	35	view →
LAML	DFS	Quartile	All	0.604	0.328	.003	30	view →
LIHC	OS	Tertile	III,IV	0.120	0.564	.001	27	view →
LUSC	DFS	Tertile	III,IV	0.369	0.635	.004	18	view →
ESCA	DFS	Quartile	All	0.394	0.615	.003	16	view →
CHOL	OS	Quartile	All	0.361	0.872	.002	12	view →
GBM	OS	Quartile	All	0.240	0.578	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SIX3-AS1–KIRC (DFS)

Open the KIRC breakdown →