SIX1

Across TCGA patient cohorts, SIX1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,432 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SIX1-associated proteins across cancer lineages are ZFHX3_S3432, SH3BP4, and SIX1_S204. Each is linked with SIX1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIX1-to-partner and partner-to-SIX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIX1 versus ZFHX3_S3432 in OV, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX1→partner) and Y-score (partner→SIX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZFHX3_S3432 →	+0.793	+1.556	.001	<.001	3	6
OV	SH3BP4 →	+0.374	+1.346	<.001	<.001	3	5
LUAD	SIX1_S204 →	+1.751	+2.320	<.001	<.001	3	5
LSCC	SIX4 →	+0.614	+1.223	<.001	<.001	3	5
UCEC	FOXA1_S331 →	+1.872	+1.775	<.001	<.001	3	5
HNSC	TUBA4A →	-0.583	-0.793	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,432 associations by consensus.

SIX1 vs ZFHX3_S3432 — OV

Explore this scatter interactively →