SIX1

Across TCGA pan-cancer cohorts, SIX1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated SIX1 data layer compared with 6 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SIX1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SIX1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and LUAD show a favorable association.

KIRP, UCEC, and ACC are the cancer types where SIX1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.522	0.810	<.001	131	view →
UCEC	DFS	Median	All	0.561	0.734	<.001	80	view →
ACC	OS	Quartile	All	0.348	0.955	<.001	71	view →
LUSC	OS	Tertile	All	0.854	0.734	<.001	57	view →
LUAD	OS	Quartile	All	0.457	0.172	.001	45	view →
UVM	DFS	Quartile	III,IV	0.243	0.793	.003	44	view →
OV	OS	Tertile	IV	0.555	0.294	.014	36	view →
SARC	OS	Quartile	All	0.616	0.893	<.001	32	view →
CHOL	OS	Median	II,III,IV	0.317	0.748	.008	27	view →
LIHC	OS	Median	All	0.423	0.701	.001	21	view →
GBM	DFS	Quartile	All	0.532	0.167	.002	12	view →
CESC	DFS	Tertile	IV	0.526	0.099	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

SIX1–KIRP (OS)

Open the KIRP breakdown →