SIX1

Across TCGA patient cohorts, SIX1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,389 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIX1-associated genes across cancer lineages are SALRNA1, SIX4, and MNAT1. Each is linked with SIX1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIX1-to-partner and partner-to-SIX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIX1 versus SALRNA1 in LUAD, with a Pearson correlation of 0.88.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX1→partner) and Y-score (partner→SIX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SALRNA1 →	+2.542	+1.738	<.001	<.001	3	5
UCEC	SIX4 →	+1.233	+1.872	<.001	<.001	3	4
GBM	MNAT1 →	+0.720	+1.183	<.001	.001	3	3
UCEC	SRMP2 →	+0.843	+1.742	.008	.007	2	4
UCEC	PF4V1 →	+1.619	+1.610	.004	.007	3	2
UCEC	FMO6P →	+1.458	+1.233	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,389 associations by consensus.

SIX1 vs SALRNA1 — LUAD

Explore this scatter interactively →