SIX1

Across TCGA patient cohorts, SIX1 mutation is significantly associated with the RNA expression of many other genes, with 2,696 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIX1-associated genes across cancer lineages are RNU6ATAC40P, MFNG, and LMF2. Each is linked with SIX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX1-to-partner and partner-to-SIX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6ATAC40P grouped by SIX1-low versus SIX1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX1→partner) and Y-score (partner→SIX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6ATAC40P →	+0.517	+3.101	.001	.004	3	2
UCEC	MFNG →	+0.790	+3.512	<.001	.002	3	2
UCEC	LMF2 →	+0.435	+3.947	.005	<.001	3	2
UCEC	FOXRED2 →	+0.749	+2.534	<.001	.001	3	2
UCEC	IL2RB →	+1.039	+3.180	<.001	<.001	3	2
UCEC	TRMU →	+0.470	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,696 associations by consensus.

RNU6ATAC40P by SIX1 expression — COAD

Explore this box plot interactively →