SIX1

Across TCGA patient cohorts, SIX1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIX1-associated genes across cancer lineages are Notch1, EGFR_pY1068, and Gab2. Each is linked with SIX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX1-to-partner and partner-to-SIX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SIX1-low versus SIX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX1→partner) and Y-score (partner→SIX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.179	+2.183	.002	.033	3	2
UCEC	EGFR_pY1068 →	-0.279	-3.584	.007	.002	3	1
UCEC	Gab2 →	+0.378	+1.807	.010	.027	3	1
UCEC	MEK1 →	+0.392	+2.321	.009	.006	3	1
UCEC	MSH2 →	-0.265	-3.295	.005	.009	3	1
UCEC	mTOR_pS2448 →	-0.126	-1.807	.040	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Notch1 by SIX1 expression — UCEC

Explore this box plot interactively →