SIX1

Across TCGA cell cohorts, SIX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,347 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SIX1-associated GO terms across cancer lineages are Olfactory placode development, Olfactory placode morphogenesis, and Olfactory placode formation. Each is linked with SIX1 in more than 18 cancer types. Because this analysis shows association rather than direction, both SIX1-to-partner and partner-to-SIX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Olfactory placode development grouped by SIX1-low versus SIX1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX1→partner) and Y-score (partner→SIX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Olfactory placode development →	+1.550	+2.071	<.001	<.001	3	19
OESOPHAGUS	Olfactory placode morphogenesis →	+1.550	+2.071	<.001	<.001	3	19
OESOPHAGUS	Olfactory placode formation →	+1.550	+2.071	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Fungiform papilla development →	-0.222	-1.944	.003	<.001	3	18
LUNG_NSCLC_LUSC	Fungiform papilla morphogenesis →	-0.222	-1.944	.003	<.001	3	18
SOFT_TISSUE	Ectodermal placode formation →	-0.165	-2.621	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,347 associations by consensus.

Olfactory placode development by SIX1 expression — OESOPHAGUS

Explore this box plot interactively →