SIX1

Across TCGA cell cohorts, SIX1 mutation is significantly associated with the drug of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIX1-associated genes across cancer lineages are ICL1100013, GSK2110183B, and Fulvestrant. Each is linked with SIX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX1-to-partner and partner-to-SIX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ICL1100013 grouped by SIX1-low versus SIX1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX1→partner) and Y-score (partner→SIX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ICL1100013 →	+0.696	+2.807	.020	.045	3	1
LARGE_INTESTINE	GSK2110183B →	+0.763	+3.000	.003	.014	3	1
LARGE_INTESTINE	Fulvestrant →	+0.358	+2.064	.015	.035	3	1
LARGE_INTESTINE	123829 →	+0.635	+3.048	.011	.007	3	1
LARGE_INTESTINE	Sabutoclax →	+0.468	+3.354	.010	.003	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.528	+3.231	.014	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ICL1100013 by SIX1 expression — LARGE_INTESTINE

Explore this box plot interactively →