SIRT5

Across TCGA patient cohorts, SIRT5 protein abundance is significantly associated with the RNA expression of many other genes, with 8,787 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIRT5-associated genes across cancer lineages are GOT1, BLOC1S5, and TRGV2. Each is linked with SIRT5 in more than 3 cancer types. Because this analysis shows association rather than direction, both SIRT5-to-partner and partner-to-SIRT5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIRT5 versus GOT1 in HNSC, with a Pearson correlation of 0.25.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT5→partner) and Y-score (partner→SIRT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GOT1 →	+0.778	+0.214	.004	.005	3	4
HNSC	BLOC1S5 →	+0.445	+0.227	.002	<.001	3	4
BRCA	TRGV2 →	-0.616	-0.257	<.001	.004	3	4
LSCC	TTLL12 →	+0.810	+0.350	<.001	.001	3	3
UCEC	GPRC5B →	+1.122	+0.269	<.001	<.001	3	3
GBM	NKAIN2 →	+1.218	+0.172	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,787 associations by consensus.

SIRT5 vs GOT1 — HNSC

Explore this scatter interactively →