SIRT5

Across TCGA pan-cancer cohorts, SIRT5 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SIRT5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SIRT5 RNA is repressed in tumor relative to normal tissue. In most cancer types SIRT5 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, HNSC, and KIRC are the cancer types where SIRT5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIRT5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−0.837	<.001	11	view →
HNSC	All	III,IV	+0.500	.001	7	view →
KIRC	Male	II,III,IV	−0.330	.001	6	view →
STAD	All	II,III,IV	+0.506	.002	4	view →
LUSC	All	All	+0.413	<.001	4	view →
CHOL	All	II,III,IV	+0.889	.040	2	view →
READ	Female	All	+0.623	.035	2	view →
BLCA	All	All	+0.400	.037	2	view →
UCEC	All	All	−0.358	.046	2	view →
COAD	Male	All	+0.330	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SIRT5–THCA

Open the THCA breakdown →