SIRT5

Across TCGA cell cohorts, SIRT5 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIRT5-associated genes across cancer lineages are ACER1, SERPINA12, and TRIM49B. Each is linked with SIRT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT5-to-partner and partner-to-SIRT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by SIRT5-low versus SIRT5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT5→partner) and Y-score (partner→SIRT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.105	+3.823	<.001	.006	3	1
BLOOD_Leukemia	SERPINA12 →	+0.047	+4.060	<.001	.003	3	1
BLOOD_Leukemia	TRIM49B →	+0.111	+3.874	<.001	.005	3	1
BLOOD_Leukemia	IL27 →	+0.149	+3.818	<.001	.007	3	1
BLOOD_Leukemia	TMEM244 →	+0.277	+3.551	<.001	.009	3	1
BLOOD_Leukemia	PNLIPRP3 →	+0.012	+3.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ACER1 by SIRT5 expression — LARGE_INTESTINE

Explore this box plot interactively →