SIK3

Across TCGA cell cohorts, SIK3 mutation is significantly associated with the RNA expression of many other genes, with 497 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIK3-associated genes across cancer lineages are MRPS27, KDSR, and WDR36. Each is linked with SIK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIK3-to-partner and partner-to-SIK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS27 grouped by SIK3-low versus SIK3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIK3→partner) and Y-score (partner→SIK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MRPS27 →	+0.643	+3.321	<.001	.003	3	2
LARGE_INTESTINE	KDSR →	+0.645	+2.628	.004	.002	3	2
LARGE_INTESTINE	WDR36 →	+0.720	+3.743	<.001	<.001	3	2
LARGE_INTESTINE	LYG1 →	+0.716	+3.169	.005	.009	3	2
LARGE_INTESTINE	ZNF232 →	+0.838	+3.257	<.001	.002	3	2
LARGE_INTESTINE	DTWD2 →	+0.565	+2.628	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 497 associations by consensus.

MRPS27 by SIK3 expression — LARGE_INTESTINE

Explore this box plot interactively →