SIK3

Across TCGA pan-cancer cohorts, SIK3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SIK3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SIK3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SIK3 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

HNSC, COAD, and THCA are the cancer types where SIK3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIK3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.436	<.001	10	view →
COAD	All	All	−0.412	<.001	10	view →
THCA	Male	All	−0.818	<.001	8	view →
KIRP	Male	All	−0.759	<.001	8	view →
KIRC	Male	II,III,IV	−0.540	<.001	7	view →
BRCA	All	All	−0.489	<.001	6	view →
LIHC	All	All	+0.305	.006	6	view →
UCEC	All	All	−0.573	.005	4	view →
BLCA	All	All	−0.509	.013	4	view →
LUAD	All	IV	+0.870	.008	2	view →
READ	All	All	−0.600	.003	2	view →
KICH	All	All	−0.500	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SIK3–HNSC

Open the HNSC breakdown →