SIK1

Across TCGA cell cohorts, SIK1 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIK1-associated genes across cancer lineages are TKTL2, NEUROD4, and SERPINI2. Each is linked with SIK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIK1-to-partner and partner-to-SIK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TKTL2 grouped by SIK1-low versus SIK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIK1→partner) and Y-score (partner→SIK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TKTL2 →	+0.038	+2.924	<.001	.002	2	3
BLOOD_Myeloma	NEUROD4 →	+0.006	+4.807	<.001	.006	3	1
STOMACH	SERPINI2 →	+0.335	+3.736	.003	.006	3	1
SKIN	MFRP →	+0.014	+3.684	<.001	.006	3	1
LARGE_INTESTINE	TNRC6B →	+1.022	+3.064	<.001	.009	3	1
LARGE_INTESTINE	RAI1 →	+0.817	+3.064	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

TKTL2 by SIK1 expression — LARGE_INTESTINE

Explore this box plot interactively →