SIK1

Across TCGA pan-cancer cohorts, SIK1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated SIK1 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SIK1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SIK1 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCS show a favorable association.

LUSC, COAD, and UCS are the cancer types where SIK1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	II,III,IV	0.665	0.812	.003	49	view →
COAD	OS	Quartile	IV	0.874	0.105	.005	28	view →
UCS	DFS	Tertile	IV	0.942	0.403	.024	24	view →
READ	OS	Quartile	III,IV	0.824	0.492	.004	14	view →
DLBC	OS	Median	II,III,IV	0.529	1.000	.016	12	view →
STAD	DFS	Quartile	All	0.306	0.470	.022	11	view →
MESO	OS	Quartile	III,IV	0.286	0.581	.013	11	view →
ACC	DFS	Quartile	All	0.176	0.754	.008	10	view →
PAAD	OS	Quartile	II,III,IV	0.356	0.541	.028	10	view →
OV	OS	Median	III,IV	0.717	0.646	.005	8	view →
BLCA	OS	Quartile	III,IV	0.603	0.401	.036	7	view →
ESCA	OS	Quartile	II,III,IV	0.634	0.819	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

SIK1–LUSC (OS)

Open the LUSC breakdown →