SIGLEC9

Across TCGA patient cohorts, SIGLEC9 mutation is significantly associated with the RNA expression of many other genes, with 4,273 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIGLEC9-associated genes across cancer lineages are PXMP2, ZNF271P, and RITA1. Each is linked with SIGLEC9 in more than 3 cancer types. Because this analysis shows association rather than direction, both SIGLEC9-to-partner and partner-to-SIGLEC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PXMP2 grouped by SIGLEC9-low versus SIGLEC9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIGLEC9→partner) and Y-score (partner→SIGLEC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PXMP2 →	+0.712	+2.180	<.001	.002	3	4
UCEC	ZNF271P →	+0.391	+2.180	.005	.002	3	4
UCEC	RITA1 →	+0.626	+4.456	<.001	<.001	3	4
LUSC	RPL23AP71 →	+0.161	+2.919	<.001	.002	3	3
SKCM	ZFYVE19 →	+0.361	+2.857	<.001	.001	3	3
SKCM	COX11 →	+0.501	+2.449	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,273 associations by consensus.

PXMP2 by SIGLEC9 expression — UCEC

Explore this box plot interactively →